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KMID : 0545120120220060814
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 6 p.814 ~ p.817
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Inhibitory Effect of Melanogenesis by 5-Pentyl-2-Furaldehyde Isolated from Clitocybe sp.
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Kim Young-Hee
Choo Soo-Jin
Ryoo In-Ja
Kim Bo-Yeon
Ahn Jong-Seog
Yoo Ick-Dong
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Abstract
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In the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography, Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5- pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC50 value of 8.4 μg/ml, without cytotoxicity.
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KEYWORD
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B16F10 melanoma, Clitocybe sp., melanogenesis, 5-pentyl-2-furaldehyde
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